Changes in the Structural and Functional Albumin Properties in Patients with Decompensated Liver Cirrhosis

А im: to conduct a comparative analysis of serum albumin's structural and functional properties in decompensated cirrhotic patients by means spin prob EPR spectroscopy. Materials methods. The main study group included 70 with liver cirrhosis ascites. control consisted 12 healthy volunteers, comparable gender age, without diseases. To assess the ability, albumin was analyzed Results. Albumin levels within reference intervals were found 37 (59.8 %). native index decrease as disease progressed lowest values Child – Pugh C ( p < 0.001). binding efficiency decreased accordance severity minimal capacity (Me = 25.43 %; n 30; transport activity RTQ cirrhosis, ability observed 26.09 In detoxification potential significantly reduced: B — Me 44.03 =17.16 %. Despite normal 72.5% 26.7% group, only 12.3% had function nо function. Conclusion. There not concentration depletion patients, but also physiological non-oncotic violated. these changes increased progression cirrhosis. Our data allow us raise question need use test determine indications for replacement therapy presence ascites, even at its concentration.